Dermatologic disorders associated with chronic hepatitis C: Effect of interferon therapy

被引：43

作者：

Berk, David R.

Bayliss Mallory, Susan

Keeffe, Emmet B.

Ahmed, Aijaz ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, Div Dermatol, St Louis, MO 63110 USA

[2] Stanford Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2007年 / 5卷 / 02期

关键词：

D O I：

10.1016/j.cgh.2006.06.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic hepatitis C virus infection (HCV) is associated with extrahepatic manifestations, including such dermatologic conditions as mixed cryoglobuhnemia, porphyria cutanea tarda, and lichen planus. Patients with chronic HCV and extrahepatic manifestations are often excluded from clinical trials evaluating interferon (IFN) therapy due to concerns about poor response, adverse events, and toxicity. Thus, data regarding the efficacy of IFN not only on the underlying chronic HCV, but also on extrahepatic manifestations, are limited in these patients. Case reports suggest that the response of dermatologic extrahepatic manifestations to IFN in patients with chronic HCV is highly variable. This review summarizes available data on dermatologic conditions associated with chronic HCV and their response to IFN therapy.

引用

页码：142 / 151

页数：10

共 172 条

[101] Lichen planus and hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review [J].