A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

被引:224
作者
Carlborg, C. F. [1 ]
Gylfason, K. B. [1 ]
Kazmierczak, A. [2 ]
Dortu, F. [2 ]
Banuls Polo, M. J. [3 ]
Maquieira Catala, A. [3 ]
Kresbach, G. M. [4 ]
Sohlstrom, H. [1 ]
Moh, T. [1 ]
Vivien, L. [5 ]
Popplewell, J.
Ronan, G.
Barrios, C. A. [6 ]
Stemme, G. [1 ]
van der Wijngaart, W. [1 ]
机构
[1] KTH Royal Inst Technol, Microsyst Technol Lab, SE-10044 Stockholm, Sweden
[2] Multitel Asbl, B-7000 Mons, Belgium
[3] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain
[4] Zeptosens, CH-4108 Witterswil, Switzerland
[5] Univ Paris 11, Inst Elect Fondamentale, F-91405 Orsay, France
[6] Univ Politecn Madrid, Inst Sistemas Optoelect & Microtecnol, E-28040 Madrid, Spain
关键词
MICRORING RESONATOR; SILICON; INTERFACE; BIOSENSOR; SYSTEMS;
D O I
10.1039/b914183a
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 x 10(-6) refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm(-2), to our knowledge the best reported values for integrated planar ring resonators.
引用
收藏
页码:281 / 290
页数:10
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