Treatment of skeletally mature ovariectomized rhesus monkeys with PTH(1-84) for 16 months increases bone formation and density and improves trabecular architecture and biomechanical properties at the lumbar spine

被引：40

作者：

Fox, John

Miller, Michael A.

Newman, Michael K.

Turner, Charles H.

Recker, Robert R.

Smith, Susan Y.

机构：

[1] NPS Pharmaceut Inc, Salt Lake City, UT 84108 USA

[2] Indiana Univ, Dept Orthopaed Surg, Indianapolis, IN USA

[3] Creighton Univ, Osteoporosis Res Ctr, Omaha, NE 68178 USA

[4] Charles River Labs, Preclin Serv, Montreal, PQ, Canada

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 02期

关键词：

ovariectomized primate; PTH; bone turnover markers; bone densitometry; bone histomorphometry; bone strength;

D O I：

10.1359/JBMR.061101

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Histomorphometric studies of treatments for osteoporosis in humans are restricted to iliac crest biopsies. We studied the effects of PTH(1-84) treatment at the lumbar spine of skeletally mature ovariectomized rhesus monkeys. PTH increased bone turnover, rapidly normalized BMD, and increased vertebral compressive strength. PTH increased trabecular bone volume primarily by increasing trabecular number by markedly increasing intratrabecular tunneling.

引用

页码：260 / 273

页数：14

共 36 条

[31] Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: A comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893 [J].