The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

被引：31

作者：

Shehu-Xhilaga, Miranda ^{[1
,2
]}

Rhodes, David ^{[3
]}

Wightman, Fiona ^{[1
,2
]}

Liu, Hong B. ^{[4
]}

Solomon, Ajantha ^{[1
,2
]}

Saleh, Suha ^{[1
,2
]}

Dear, Anthony E. ^{[4
]}

Cameron, Paul U. ^{[1
,2
]}

Lewin, Sharon R. ^{[1
,2
,5
]}

机构：

[1] Alfred Hosp, Infect Dis Unit, Sydney, NSW, Australia

[2] Monash Univ, Dept Med, Clayton, Vic 3800, Australia

[3] Avexa Ltd, Richmond, VA USA

[4] Monash Univ, Australian Ctr Blood Dis, Clayton, Vic 3800, Australia

[5] Burnet Inst, Ctr Virol, Melbourne, Vic, Australia

来源：

AIDS | 2009年 / 23卷 / 15期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

SUBEROYLANILIDE HYDROXAMIC ACID; CD4(+) T-CELLS; VALPROIC ACID; CANCER CELLS; IN-VITRO; EXPRESSION; RESERVOIR; RECRUITMENT; OXAMFLATIN; STABILITY;

D O I：

10.1097/QAD.0b013e328330342c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the ability of several novel class I histone deacetylase inhibitors to activate HIV-1 transcription in latently infected cell lines. Oxamflatin, metacept-1 and metacept-3 induced high levels of HIV-1 transcription in latently infected T cell and monocytic cells lines, were potent inhibitors of histone deacetylase activity and caused preferential cell death in transcriptionally active cells. Although these compounds had potent in-vitro activity, their cytotoxicity may limit their use in patients.

引用

页码：2047 / 2050

页数：4

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