Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

被引：18

作者：

David-Cordonnier, Marie-Helene

Casely-Hayford, Maxwell

Kouach, Mostafa

Briand, Gilbert

Patterson, Laurence H.

Bailly, Christian

Searcey, Mark

机构：

[1] Univ London, Sch Pharm, London WC1N 1AX, England

[2] INSERM, U 814, IRCL, F-59045 Lille, France

[3] Univ Lille 2, Spectrometrie Masse Lab, F-59045 Lille, France

[4] Univ Bradford, Inst Canc Therapeut, Bradford BD7 1DP, W Yorkshire, England

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 11期

关键词：

antitumor agents; azinomycin; depurination; DNA cleavage; natural products;

D O I：

10.1002/cbic.200600244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).

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页码：1658 / +

页数：5

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