Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

被引：14

作者：

Akiho, Mai ^{[1
]}

Nakashima, Hiroyuki ^{[1
]}

Sakata, Munehiro ^{[2
]}

Yamasa, Yuka ^{[2
]}

Yamaguchi, Akihiko ^{[3
]}

Sakuma, Kunihiro ^{[1
]}

机构：

[1] Toyohashi Univ Technol, Res Ctr Phys Fitness Sports & Hlth, Toyohashi, Aichi 4418580, Japan

[2] Kyoto Prefectural Univ Med, Dept Legal Med, Kamigyo Ku, Kyoto 6028566, Japan

[3] Hlth Sci Univ Hokkaido, Sch Dent, Kanazawa Ku, Ishikari, Hokkaido 06102, Japan

来源：

LIFE SCIENCES | 2010年 / 86卷 / 1-2期

关键词：

Notch-1; Myogenin; Satellite cell; Skeletal muscle; Hypertrophy; SATELLITE CELL ACTIVATION; SKELETAL-MUSCLE; PROGENITOR CELLS; RBP-J; MYOGENIC DIFFERENTIATION; POSTNATAL MYOGENESIS; FIBER HYPERTROPHY; STEM-CELLS; PATHWAY; REGENERATION;

D O I：

10.1016/j.lfs.2009.11.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice. Main methods: We performed immunofluorescence of both Notch-1 and the Notch-l-linking molecules. Key findings: immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2-6. We observed clear co-localization between Notch-1 and myogenin (4.9 +/- 1.3%) in the hypertrophied muscle at 4 days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1 +/- 1.2%). Significance: Notch-1 may play an important role in the maintenance of quiescent satellite cells. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：59 / 65

页数：7

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