Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides

被引：14

作者：

Bornholdt, Jan ^{[1
]}

Fjaere, Karianne Wilhemsen ^{[1
]}

Felding, Jakob ^{[2
]}

Kristensen, Jesper Langgaard ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Med Chem, Fac Pharmaceut Sci, DK-2100 Copenhagen, Denmark

[2] Leo Pharma AS, DK-2750 Ballerup, Denmark

来源：

TETRAHEDRON | 2009年 / 65卷 / 45期

关键词：

PROTECTION;

D O I：

10.1016/j.tet.2009.09.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heterocyclic pentafluorophenyl sulfonate esters are shelf stable alternatives to the often less stable sulfonyl chlorides. They are easily prepared from thiols and react readily with primary and secondary amines to produce sulfonamides in high yields. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：9280 / 9284

页数：5

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