Biocatalytic Friedel-Crafts Alkylation Using Non-natural Cofactors

被引：96

作者：

Stecher, Harald ^{[1
,2
]}

Tengg, Martin ^{[1
,3
]}

Ueberbacher, Bernhard J. ^{[1
]}

Remler, Peter ^{[1
]}

Schwab, Helmut ^{[3
]}

Griengl, Herfried ^{[1
]}

Gruber-Khadjawi, Mandana ^{[1
,2
]}

机构：

[1] Kompetenzzentrum Angew Biokatalyse, A-8010 Graz, Austria

[2] Graz Univ Technol, Inst Organ Chem, A-8010 Graz, Austria

[3] Graz Univ Technol, Inst Mol Biotechnol, A-8010 Graz, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 50期

关键词：

biocatalysis; C-C coupling; Friedel-Crafts alkylation; S-adenosyl-L-methionine; sustainable chemistry; C BOND FORMATION; STREPTOMYCES-RISHIRIENSIS; HYDROXYNITRILE LYASE; HENRY REACTION; GENE-CLUSTER; COUMERMYCIN; METHYLTRANSFERASES; BIOSYNTHESIS; DERIVATIVES;

D O I：

10.1002/anie.200905095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel biocatalytic protocol for C -C bond formation is described and is an equivalent to Friedel-Crafts alkylation. S-Adenosyl-L-methionine (SAM), the major Chemical Equation Presentation methyl donor for biological methylation catalyzed by methyltransferases (Mtases), can perform alkylations (see scheme). These enzymes can accept non-natural cofactors and transfer functionalities other than methyl onto aromatic substrates © 2009 Wiley-VCH Verlag GmbH Co. KCaA.

引用

页码：9546 / 9548

页数：3

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