Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions

被引：61

作者：

Bindu, B. ^{[1
]}

Alladi, P. A. ^{[1
]}

Mansooralikhan, B. M. ^{[1
]}

Srikumar, B. N. ^{[1
]}

Raju, T. R. ^{[1
]}

Kutty, B. M. ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore 560029, Karnataka, India

来源：

NEUROSCIENCE | 2007年 / 144卷 / 02期

关键词：

brain lesion; dendritic atrophy; neuronal plasticity;

D O I：

10.1016/j.neuroscience.2006.09.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Environmental enrichment promotes structural and behavioral plasticity in the adult brain. We have evaluated the efficacy of enriched environment on the dendritic morphology and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of ventral subicular-lesioned rats. Bilateral ventral subicular lesion has significantly reduced the dendritic architecture and spine density of hippocampal pyramidal neurons. The lesioned rats exposed to enriched housing for 10 days showed a significant degree of morphological plasticity in terms of enhanced dendritic branching and spine density. However, the BDNF expression in the hippocampus remained unchanged following subicular lesion and following environmental enrichment. We suggest the participation of other neurotrophic factors in mediating the synaptic plasticity events following exposure to environmental enrichment in ventral subicular-lesioned rats. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：412 / 423

页数：12

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