Autoimmunity vs autoinflammation in Behcet's disease:: do we oversimplify a complex disorder?

被引：150

作者：

Direskeneli, H. ^{[1
]}

机构：

[1] Marmara Univ, Fac Med, Div Rheumatol, Istanbul, Turkey

来源：

RHEUMATOLOGY | 2006年 / 45卷 / 12期

关键词：

Behcet's disease; innate; adaptive; pathogenesis;

D O I：

10.1093/rheumatology/kel329

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Behcet's disease (BD) is a systemic inflammatory disorder with a diverse spectrum of clinical manifestations including mucocutaneous, ocular, vascular, gastrointestinal, musculoskeletal and central nervous system involvement [1]. A complex genetic background leading to a pro-inflammatory, innate-immune-system-derived activation perpetuated by adaptive immune responses against enviromental and auto-antigens is accepted to be the hallmark of BD [2]. This review aims to make an in-depth critical analysis of current data for recent controversies on the role of innate immune system vs autoimmunity in BD [3-5].

引用

页码：1461 / 1465

页数：5

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