Connecting viral with cellular interactomes

被引：50

作者：

Bailer, S. M. ^{[1
]}

Haas, J. ^{[1
,2
]}

机构：

[1] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany

[2] Univ Edinburgh, Div Pathway Med, Edinburgh EH16 4SB, Midlothian, Scotland

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 04期

关键词：

EPSTEIN-BARR-VIRUS; PROTEIN-PROTEIN INTERACTIONS; INTERACTION MAP; INTERACTION NETWORK; IDENTIFICATION; BFLF2; BFRF1; PROTEOMICS; LANDSCAPE; COMPLEXES;

D O I：

10.1016/j.mib.2009.06.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genome-scale screens for intraviral and virus-host protein interactions and the analysis of literature-curated datasets are able to provide a novel, comprehensive perspective of viruses, and virus-infected cells. Until now, large-scale interaction screens were predominantly performed with the yeast-two-hybrid (Y2H) system; however, alternative high-throughput technologies detecting binary protein interactions or protein complexes have been developed. Although many of the previous studies suffer from a rather poor validation of the results and few biological implications, these technologies potentially lead to a plethora of novel hypotheses. Here, we will give an overview of current approaches and their technical limitations, present recent examples and novel developments.

引用

页码：453 / 459

页数：7

共 49 条

[1] High-throughput mapping of a dynamic signaling network in mammalian cells [J].

Barrios-Rodiles, M ;

Brown, KR ;

Ozdamar, B ;

Bose, R ;

Liu, Z ;

Donovan, RS ;

Shinjo, F ;

Liu, YM ;

Dembowy, J ;

Taylor, IW ;

Luga, V ;

Przulj, N ;

Robinson, M ;

Suzuki, H ;

Hayashizaki, Y ;

Jurisica, I ;

Wrana, JL .

SCIENCE, 2005, 307 (5715) :1621-1625

[2] A physical and functional map of the human TNF-α NF-κB signal transduction pathway [J].

Bouwmeester, T ;

Bauch, A ;

Ruffner, H ;

Angrand, PO ;

Bergamini, G ;

Croughton, K ;

Cruciat, C ;

Eberhard, D ;

Gagneur, J ;

Ghidelli, S ;

Hopf, C ;

Huhse, B ;

Mangano, R ;

Michon, AM ;

Schirle, M ;

Schlegl, J ;

Schwab, M ;

Stein, MA ;

Bauer, A ;

Casari, G ;

Drewes, G ;

Gavin, AC ;

Jackson, DB ;

Joberty, G ;

Neubauer, G ;

Rick, J ;

Kuster, B ;

Superti-Furga, G .

NATURE CELL BIOLOGY, 2004, 6 (02) :97-+

[3]

Braun P, 2009, NAT METHODS, V6, P91, DOI [10.1038/NMETH.1281, 10.1038/nmeth.1281]

[4] Comprehensive mutational analysis of a herpesvirus gene in the viral genome context reveals a region essential for virus replication [J].

Bubeck, A ;

Wagner, M ;

Ruzsics, Z ;

Lötzerich, M ;

Iglesias, M ;

Singh, IR ;

Koszinowski, UH .

JOURNAL OF VIROLOGY, 2004, 78 (15) :8026-8035

[5] An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells [J].

Buerckstuemmer, Tilmann ;

Bennett, Keiryn L. ;

Preradovic, Adrijana ;

Schutze, Gregor ;

Hantschel, Oliver ;

Superti-Furga, Giulio ;

Bauch, Angela .

NATURE METHODS, 2006, 3 (12) :1013-1019

[6] Epstein-Barr virus and virus human protein interaction maps [J].

Calderwood, Michael A. ;

Venkatesan, Kavitha ;

Xing, Li ;

Chase, Michael R. ;

Vazquez, Alexel ;

Holthaus, Amy M. ;

Ewence, Alexandra E. ;

Li, Ning ;

Hirozane-Kishikawa, Tomoko ;

Hill, David E. ;

Vidal, Marc ;

Kieff, Elliott ;

Johannsen, Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) :7606-7611

[7]

Cusick ME, 2009, NAT METHODS, V6, P39, DOI [10.1038/NMETH.1284, 10.1038/nmeth.1284]

[8] Hepatitis C virus infection protein network [J].

de Chassey, B. ;

Navratil, V. ;

Tafforeau, L. ;

Hiet, M. S. ;

Aublin-Gex, A. ;

Agaugue, S. ;

Meiffren, G. ;

Pradezynski, F. ;

Faria, B. F. ;

Chantier, T. ;

Le Breton, M. ;

Pellet, J. ;

Davoust, N. ;

Mangeot, P. E. ;

Chaboud, A. ;

Penin, F. ;

Jacob, Y. ;

Vidalain, P. O. ;

Vidal, M. ;

Andre, P. ;

Rabourdin-Combe, C. ;

Lotteau, V. .

MOLECULAR SYSTEMS BIOLOGY, 2008, 4 (1)

[9] The landscape of human proteins interacting with viruses and other pathogens [J].

Dyer, Matthew D. ;

Murali, T. M. ;

Sobral, Bruno W. .

PLOS PATHOGENS, 2008, 4 (02)

[10] Large-scale mapping of human protein-protein interactions by mass spectrometry [J].

Ewing, Rob M. ;

Chu, Peter ;

Elisma, Fred ;

Li, Hongyan ;

Taylor, Paul ;

Climie, Shane ;

McBroom-Cerajewski, Linda ;

Robinson, Mark D. ;

O'Connor, Liam ;

Li, Michael ;

Taylor, Rod ;

Dharsee, Moyez ;

Ho, Yuen ;

Heilbut, Adrian ;

Moore, Lynda ;

Zhang, Shudong ;

Ornatsky, Olga ;

Bukhman, Yury V. ;

Ethier, Martin ;

Sheng, Yinglun ;

Vasilescu, Julian ;

Abu-Farha, Mohamed ;

Lambert, Jean-Philippe ;

Duewel, Henry S. ;

Stewart, Ian I. ;

Kuehl, Bonnie ;

Hogue, Kelly ;

Colwill, Karen ;

Gladwish, Katharine ;

Muskat, Brenda ;

Kinach, Robert ;

Adams, Sally-Lin ;

Moran, Michael F. ;

Morin, Gregg B. ;

Topaloglou, Thodoros ;

Figeys, Daniel .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)

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