Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours

被引：22

作者：

Granchi, Carlotta ^{[1
]}

Funaioli, Tiziana ^{[2
]}

Erler, Janine T. ^{[3
]}

Giaccia, Amato J. ^{[3
]}

Macchia, Marco ^{[1
]}

Minutolo, Filippo ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy

[2] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

[3] Stanford Univ, Dept Radiat Oncol, Sch Med, Stanford, CA 94305 USA

来源：

CHEMMEDCHEM | 2009年 / 4卷 / 10期

关键词：

antitumor agents; cancer; electrochemical potential; hypoxia; lysyl oxidase; prodrugs; BETA-AMINOPROPIONITRILE; METASTASIS; CYTOTOXICITY; MECHANISMS; CELLS;

D O I：

10.1002/cmdc.200900247

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) The right keys for tumour locks: Nitroaromatic and heteroaromatic portions are suitably sensitive to hypoxic conditions when used as BAPN masking groups, and the resulting prodrugs (pro-BAPNs) showed good levels of in vitro hypoxia-selective inhibition of lysyl oxidase (LOX) activity and cancer cell invasion. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：1590 / 1594

页数：5

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