Stereocontrol in solid-phase radical reactions: Radical addition to oxime ether anchored to polymer support

被引：77

作者：

Miyabe, H ^{[1
]}

Konishi, C ^{[1
]}

Naito, T ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 10期

关键词：

D O I：

10.1021/ol005771m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A high degree of stereocontrol in solid phase radical reactions was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature. Alkyl radical addition to Oppolzer's camphorsultam derivatives of oxime ether anchored to polymer support proceeded smoothly to give the alpha-amino acid derivatives with excellent diastereoselectivities.

引用

页码：1443 / 1445

页数：3

共 30 条

[1]

Berteina S, 1998, SYNLETT, P1231

[2] Application of radical chemistry to solid support synthesis [J].