Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments

被引:56
作者
Clancy, Cornelius J.
Huang, Hong
Cheng, Shaoji
Derendorf, Hartmut
Nguyen, M. Hong
机构
[1] Univ Florida, Coll Med, Dept Med, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA
[3] N Florida S Georgia VA Med Ctr, Gainesville, FL 32610 USA
[4] Univ Florida, Coll Pharm, Dept Pharmaceut, Gainesville, FL 32610 USA
关键词
D O I
10.1128/AAC.00291-06
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.
引用
收藏
页码:2569 / 2572
页数:4
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