Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments

被引：56

作者：

Clancy, Cornelius J.

Huang, Hong

Cheng, Shaoji

Derendorf, Hartmut

Nguyen, M. Hong

机构：

[1] Univ Florida, Coll Med, Dept Med, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA

[3] N Florida S Georgia VA Med Ctr, Gainesville, FL 32610 USA

[4] Univ Florida, Coll Pharm, Dept Pharmaceut, Gainesville, FL 32610 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期

关键词：

D O I：

10.1128/AAC.00291-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

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页码：2569 / 2572

页数：4

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