In vitro pharmacodynamic characteristics of amphotericin B, caspofungin, fluconazole, and voriconazole against bloodstream isolates of infrequent Candida species from patients with hematologic malignancies

被引：44

作者：

Di Bonaventura, G

Spedicato, I

Picciani, C

D'Antonio, D

Piccolomini, R

机构：

[1] Univ G DAnnunzio, Ctr Excellence Aging, Dept Biomed Sci, Lab Clin Microbiol, I-66100 Chieti, Italy

[2] G DAnnunzio Univ Fdn, CeSI, Aging Res Ctr, Chieti, Italy

[3] Spirito Santo Hosp, Dept Hematol & Oncol, Clin Microbiol Serv, Pescara, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 11期

关键词：

D O I：

10.1128/AAC.48.11.4453-4456.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Time-kill and postantifungal effect (PAFE) of amphotericin B, caspofungin, fluconazole, and voriconazole were determined against clinical isolates of Candida guilliermondii, Candida kefyr, and Candida lusitaniae. Azoles displayed fungistatic activity and no measurable PAFE, regardless of the concentration tested. Amphotericin B and caspofungin demonstrated concentration-dependent fungicidal activity, although amphotericin B only produced a significant dose-dependent PAFE against all isolates tested.

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页码：4453 / 4456

页数：4

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