New vistas on amygdala networks in conditioned fear

被引:648
作者
Paré, D
Quirk, GJ
Ledoux, JE
机构
[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
[2] Ponce Sch Med, Dept Physiol, Ponce, PR 00732 USA
[3] NYU, Ctr Neural Sci, New York, NY 10003 USA
关键词
D O I
10.1152/jn.00153.2004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It is currently believed that the acquisition of classically conditioned fear involves potentiation of conditioned thalamic inputs in the lateral amygdala ( LA). In turn, LA cells would excite more neurons in the central nucleus ( CE) that, via their projections to the brain stem and hypothalamus, evoke fear responses. However, LA neurons do not directly contact brain stem-projecting CE neurons. This is problematic because CE projections to the periaqueductal gray and pontine reticular formation are believed to generate conditioned freezing and fear-potentiated startle, respectively. Moreover, like LA, CE may receive direct thalamic inputs communicating information about the conditioned and unconditioned stimuli. Finally, recent evidence suggests that the CE itself may be a critical site of plasticity. This review attempts to reconcile the current model with these observations. We suggest that potentiated LA outputs disinhibit CE projection neurons via GABAergic intercalated neurons, thereby permitting associative plasticity in CE. Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction.
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页码:1 / 9
页数:9
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