IL-24 is expressed by rat and human macrophages

被引：69

作者：

Garn, H

Schmidt, A

Grau, V

Stumpf, S

Kaufmann, A

Becker, M

Gemsa, D

Siese, A

机构：

[1] Univ Marburg, Inst Immunol, D-35037 Marburg, Germany

[2] Univ Marburg, Inst Pathol, D-35037 Marburg, Germany

[3] Univ Marburg, Inst Anat & Cell Biol, D-35037 Marburg, Germany

来源：

IMMUNOBIOLOGY | 2002年 / 205卷 / 03期

关键词：

D O I：

10.1078/0171-2985-00135

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Recently, a number of interleukin-10 (IL-10) homologues, among them IL-24 formerly known as melanocyte differentiation factor-7 (mda-7), has been described. Since IL-10 is released by macrophages and plays an important role in the resolution of inflammatory processes, we hypothesized that IL-24 might also be expressed in cells of the monocyte/macrophage lineage. We analyzed IL-24 expression on the mRNA and protein level in stimulated rat and human macrophages. In rat alveolar macrophages and NR8383 cells IL-24 mRNA induction was observed following stimulation with LPS and IL-4 whereas TNF-alpha failed. Intracellular IL-24 protein was detected in unstimulated and IL-4 stimulated NR8383 cells. Also human blood monocytes showed a strong up-regulation of IL-24 mRNA following preparation which was enhanced by LPS and lowered by IL-10. Furthermore, infection of human monocytes with influenza A virus A/PR/8 caused an induction of IL-24 mRNA expression. In conclusion, our data show that IL-24 expression is induced in stimulated and infected rat and human macrophages, however, more insights into the functions of IL-24 are necessary to define its physiological relevance.

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收藏

页码：321 / 334

页数：14

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