Both expansion of regulatory GRI+ CD11b+ myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis

被引：63

作者：

Voisin, MB

Buzoni-Gatel, D

Bout, D

Velge-Roussel, F

机构：

[1] UMR Univ INRA, UFR Sci Pharmaceut, F-37200 Tours, France

[2] INRA, Inst Pasteur, Unite Reponse Precoce Parasites, Paris, France

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 09期

关键词：

D O I：

10.1128/IAI.72.9.5487-5492.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1(+) CD11b(+) myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8(+) and CD4(+) activated T lymphocytes with infection.

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页码：5487 / 5492

页数：6

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