Evidence for limited within-person evolution of the V3 domain of the HIV-1 envelope in the Amsterdam population

被引:30
作者
Kuiken, CL [1 ]
Lukashov, VV [1 ]
Baan, E [1 ]
Dekker, J [1 ]
Leunissen, JAM [1 ]
Goudsmit, J [1 ]
机构
[1] UNIV NIJMEGEN, DEUTSCH NATL FACIL COMP AIDED CHEM & BIOINFORMAT, CAMM, CAOS, NIJMEGEN, NETHERLANDS
关键词
V3; domain; evolution; variation; molecular epidemiology;
D O I
10.1097/00002030-199601000-00005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To study the development of the V3 region of the HIV-1 envelope over time, both within subjects and population-wide. Methods: Direct V3 sequences were obtained from viral RNA from seroconversion samples of 138 individuals [32 intravenous drug users (IVDU), 106 homosexual men], as well as from 5-year follow-up samples of 45 of these individuals (11 IVDU, 34 homosexual men). Results: The population-wide variation of the V3 region in both the seroconversion samples and the 5-year samples steadily increased over consecutive years and were of similar magnitude in each calendar year. The variation in the IVDU group was slightly lower (presumably lagging behind) than in the homosexual group, but also increased over time. The consensus sequence, representing the centre of the swarm of variants, remained almost stationary in 10 years of evolution. The V3 sequences from virions in serum collected 5 years after seroconversion still resembled those from the seroconversion sample, either in overall similarity or in specific (signature) amino acids. Seroconversion and late sequences from a donor-recipient pair were also very similar. Conclusions: The variation in V3 sequences from seroconversion samples is as large as that in 5-year follow-up samples from the same calendar year, suggesting that there is no strong selection for a particular V3 genotype at transmission. The HIV-1 subtype B quasispecies in a naive population appears to evolve through unbiased expansion around a stationary consensus sequence. Despite its large variability, the V3 region retains many of its individual characteristics after 5 years of infection. This indicates that the sampling moment (relative to the seroconversion data) will not greatly influence the results of phylogenetic analyses.
引用
收藏
页码:31 / 37
页数:7
相关论文
共 56 条
[41]   COMPARISON OF VARIABLE REGION-3 SEQUENCES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 FROM INFECTED CHILDREN WITH THE RNA AND DNA-SEQUENCES OF THE VIRUS POPULATIONS OF THEIR MOTHERS [J].
SCARLATTI, G ;
LEITNER, T ;
HALAPI, E ;
WAHLBERG, J ;
MARCHISIO, P ;
CLERICISCHOELLER, MA ;
WIGZELL, H ;
FENYO, EM ;
ALBERT, J ;
UHLEN, M ;
ROSSI, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1721-1725
[42]   SMALL AMINO-ACID CHANGES IN THE V3-HYPERVARIABLE REGION OF GP120 CAN AFFECT THE T-CELL-LINE AND MACROPHAGE TROPISM OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
SHIODA, T ;
LEVY, JA ;
CHENGMAYER, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9434-9438
[43]   CONSERVED V3 LOOP SEQUENCES AND TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
SHPAER, EG ;
DELWART, EL ;
KUIKEN, CL ;
GOUDSMIT, J ;
BACHMANN, MH ;
MULLINS, JI .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (12) :1679-1684
[44]   ANALYSIS OF SEQUENCE DIVERSITY IN HYPERVARIABLE REGIONS OF THE EXTERNAL GLYCOPROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
SIMMONDS, P ;
BALFE, P ;
LUDLAM, CA ;
BISHOP, JO ;
BROWN, AJL .
JOURNAL OF VIROLOGY, 1990, 64 (12) :5840-5850
[45]   NEUTRALIZING ANTIBODIES TO AN IMMUNODOMINANT ENVELOPE SEQUENCE DO NOT PREVENT GP120 BINDING TO CD4 [J].
SKINNER, MA ;
LANGLOIS, AJ ;
MCDANAL, CB ;
MCDOUGAL, JS ;
BOLOGNESI, DP ;
MATTHEWS, TJ .
JOURNAL OF VIROLOGY, 1988, 62 (11) :4195-4200
[46]   THE CONTINUING CASE OF THE FLORIDA DENTIST [J].
SMITH, TF ;
WATERMAN, MS .
SCIENCE, 1992, 256 (5060) :1155-1156
[47]   INDUCTION OF BROADLY CROSS-REACTIVE CYTOTOXIC T-CELLS RECOGNIZING AN HIV-1 ENVELOPE DETERMINANT [J].
TAKAHASHI, H ;
NAKAGAWA, Y ;
PENDLETON, CD ;
HOUGHTEN, RA ;
YOKOMURO, K ;
GERMAIN, RN ;
BERZOFSKY, JA .
SCIENCE, 1992, 255 (5042) :333-336
[48]   FUNCTIONAL ROLES OF THE V3 HYPERVARIABLE REGION OF HIV-1 GP160 IN THE PROCESSING OF GP160 AND IN THE FORMATION OF SYNCYTIA IN CD4+ CELLS [J].
TRAVIS, BM ;
DYKERS, TI ;
HEWGILL, D ;
LEDBETTER, J ;
TSU, TT ;
HU, SL ;
LEWIS, JB .
VIROLOGY, 1992, 186 (01) :313-317
[49]  
VANDENHOEK JAR, 1988, AIDS, V2, P55, DOI 10.1097/00002030-198802000-00010
[50]   DID THE INTRODUCTION OF HIV AMONG HOMOSEXUAL MEN PRECEDE THE INTRODUCTION OF HIV AMONG INJECTING DRUG-USERS IN THE NETHERLANDS [J].
VANHAASTRECHT, HJA ;
VANDENHOEK, JAR ;
MIENTJES, GH ;
COUTINHO, RA .
AIDS, 1992, 6 (01) :131-132