Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina

被引：267

作者：

Kubicek, Christian P. ^{[1
]}

Mikus, Marianna ^{[1
]}

Schuster, Andre ^{[1
]}

Schmoll, Monika ^{[1
]}

Seiboth, Bernhard ^{[1
]}

机构：

[1] TU Vienna, Inst Chem Engn, Res Area Gene Technol & Appl Biochem, A-1060 Vienna, Austria

来源：

BIOTECHNOLOGY FOR BIOFUELS | 2009年 / 2卷

基金：

奥地利科学基金会;

关键词：

CARBON CATABOLITE REPRESSION; ANAMORPH TRICHODERMA-REESEI; CELLOBIOHYDROLASE-II-GENE; CONIDIAL-BOUND CELLULASE; D-XYLOSE METABOLISM; ASPERGILLUS-NIDULANS; BETA-GLUCOSIDASE; G-PROTEIN; LACTOSE METABOLISM; D-GALACTOSE;

D O I：

10.1186/1754-6834-2-19

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hypocrea jecorina (= Trichoderma reesei) is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.

引用

页数：14

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