Structure elucidation of a photodegradation product of ciprofloxacin

被引:36
作者
Torniainen, K
Mattinen, J
Askolin, CP
Tammilehto, S
机构
[1] UNIV HELSINKI,DEPT PHARM,PHARMACEUT CHEM DIV,FIN-00014 HELSINKI,FINLAND
[2] ABO AKAD UNIV,DEPT ORGAN CHEM,FIN-20500 TURKU,FINLAND
关键词
ciprofloxacin; photodegradation; mass spectrometry; nuclear magnetic resonance spectroscopy;
D O I
10.1016/S0731-7085(96)01921-8
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In the photochemical degradation of ciprofloxacin, 1 -cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazinyl)-3-quinolone carboxylic acid: two major decomposition products are formed in-acidic solution. The main degradation product, after both artificial and daylight exposure, was 7-amino-1 -cycioplopyl-6-fluoro- 1,4-dihydro-4-oxo-3-quinolone carboxylic acid. This product was also the dominating compound after more than 5 h irradiation with a high-pressure mercury lamp in aqueous solutions at pH less than or equal to 2 when the solvent additionally contained water-miscible organic solvent. The structure of the isolated compound was elucidated on the basis of the chemical behaviour in thin-layer and high-performance liquid chromatography, and of information from infrared, ultraviolet, mass and nuclear magnetic resonance spectra. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:887 / 894
页数:8
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