Perfect use of imperfection

被引：22

作者：

Schild, H ^{[1
]}

Rammensee, HG ^{[1
]}

机构：

[1] Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany

来源：

NATURE | 2000年 / 404卷 / 6779期

关键词：

D O I：

10.1038/35008165

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When making proteins, cells opt for high speed at the cost of large amounts of waste. But the waste-recycling process has a happy side effect — it gives the immune system a head start in its battle against viral invaders.

引用

页码：709 / 710

页数：2

共 7 条

[1] T-CELL-RECOGNIZED ANTIGENIC PEPTIDES DERIVED FROM THE CELLULAR GENOME ARE NOT PROTEIN-DEGRADATION PRODUCTS BUT CAN BE GENERATED DIRECTLY BY TRANSCRIPTION AND TRANSLATION OF SHORT SUBGENIC REGIONS - A HYPOTHESIS [J].

BOON, T ;

VANPEL, A .

IMMUNOGENETICS, 1989, 29 (02) :75-79

[2] Recognition of out-of-frame major histocompatibility complex class I-restricted epitopes in vivo [J].

Elliott, T ;

Bodmer, H ;

Townsend, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (05) :1175-1179

[3] Presentation of out-of-frame peptide MHC class I complexes by a novel translation initiation mechanism [J].

Malarkannan, S ;

Horng, T ;

Shih, PP ;

Schwab, S ;

Shastri, N .

IMMUNITY, 1999, 10 (06) :681-690

[4] Non-traditionally derived CTL epitopes: exceptions that prove the rules? [J].

Mayrand, SM ;

Green, WR .

IMMUNOLOGY TODAY, 1998, 19 (12) :551-556

[5] The major substrates for TAP in vivo are derived from newly synthesized proteins [J].

Reits, EAJ ;

Vos, JC ;

Grommé, M ;

Neefjes, J .

NATURE, 2000, 404 (6779) :774-778

[6] Rapid degradation of a large fraction of newly synthesized proteins by proteasomes [J].

Schubert, U ;

Antón, LC ;

Gibbs, J ;

Norbury, CC ;

Yewdell, JW ;

Bennink, JR .

NATURE, 2000, 404 (6779) :770-774

[7]

Yewdell JW, 1996, J IMMUNOL, V157, P1823

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