Skin immune sentinels in health and disease

被引:965
作者
Nestle, Frank O. [1 ,2 ]
Di Meglio, Paola [1 ,2 ]
Qin, Jian-Zhong [3 ]
Nickoloff, Brian J. [3 ]
机构
[1] Guys Hosp, St Johns Inst Dermatol, Kings Coll London, NIHR,Biomed Res Ctr, London SE1 9RT, England
[2] Guys Hosp, Federat Clin Immunol FOCIS, Kings Coll London, Ctr Excellence, London SE1 9RT, England
[3] Loyola Univ, Med Ctr, Dept Pathol, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA
基金
英国惠康基金; 英国医学研究理事会;
关键词
EPIDERMAL LANGERHANS CELLS; DERMAL DENDRITIC CELLS; DELTA-T-CELLS; ANTIGEN-PRESENTING CELLS; ALLERGIC CONTACT-DERMATITIS; NECROSIS-FACTOR-ALPHA; IN-VIVO; ANTIMICROBIAL PEPTIDES; ATOPIC-DERMATITIS; DISTINCT POPULATIONS;
D O I
10.1038/nri2622
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.
引用
收藏
页码:679 / 691
页数:13
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