Membrane-protein topology

被引：400

作者：

von Heijne, Gunnar ^{[1
]}

机构：

[1] Stockholm Univ, Ctr Biomembrane Res, SE-10691 Stockholm, Sweden

[2] Stockholm Univ, Stockholm Bioinformat Ctr, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 12期

关键词：

D O I：

10.1038/nrm2063

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the world of membrane proteins, topology defines an important halfway house between the amino-acid sequence and the fully folded three-dimensional structure. Although the concept of membrane-protein topology dates back at least 30 years, recent advances in the field of translocon-mediated membrane-protein assembly, proteome-wide studies of membrane-protein topology and an exponentially growing number of high-resolution membrane-protein structures have given us a deeper understanding of how topology is determined and of how it evolves.

引用

页码：909 / 918

页数：10

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