Magnetic resonance imaging and neurosphere therapy of stroke in rat

被引：79

作者：

Zheng, ZG

Jiang, Q

Zhang, RL

Zhang, L

Wang, L

Zhang, LJ

Arniego, P

Ho, KL

Chopp, M

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA

[2] Henry Ford Hlth Sci Ctr, Dept Pathol, Detroit, MI USA

[3] Oakland Univ, Dept Phys, Rochester, MI 48063 USA

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 02期

关键词：

D O I：

10.1002/ana.10467

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We intracisternally transplanted subventricular zone (SVZ) cells labeled by ferromagnetic particles into stroked rats. Migration of transplanted cells was noninvasively tracked using magnetic resonance imaging (MRI). We found that transplanted cells selectively migrated towards the ischemic parenchyma at a mean speed of 65 +/- 14.6 mum/hr in living rats. Migration of transplanted cells in the brain was also measured histopathologically. Rats transplanted with SVZ cells exhibited significant improvement of neurological function. Our data suggest that intracisternal transplantation of SVZ cells provides an avenue for cell therapy of stroke and that MRI can be used to track grafted cells in the brain.

引用

页码：259 / 263

页数：5

共 14 条

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Alvarez-Buylla A, 2000, Prog Brain Res, V127, P1

[2] Transplanted CNS stem cells form functional synapses in vivo [J].