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Mass spectrometry for genotyping: an emerging tool for molecular medicine

被引：28
作者：
Jackson, PE
Scholl, PF
Groopman, JD
机构：
[1] Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA
来源：
MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 07期
关键词：
D O I：
10.1016/S1357-4310(00)01698-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.
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收藏
页码：271 / 276
页数：6
相关论文
共 47 条
  • [1] [Anonymous], 1997, TIME FLIGHT MASS SPE
  • [2] Analysis of oligonucleotides by HPLC-electrospray ionization mass spectrometry
    Apffel, A
    Chakel, JA
    Fischer, S
    Lichtenwalter, K
    Hancock, WS
    [J]. ANALYTICAL CHEMISTRY, 1997, 69 (07) : 1320 - 1325
  • [3] Infrared MALDI mass spectrometry of large nucleic acids
    Berkenkamp, S
    Kirpekar, F
    Hillenkamp, F
    [J]. SCIENCE, 1998, 281 (5374) : 260 - 262
  • [4] Braun A, 1997, CLIN CHEM, V43, P1151
  • [5] Improved analysis of microsatellites using mass spectrometry
    Braun, A
    Little, DP
    Reuter, D
    MullerMysok, B
    Koster, H
    [J]. GENOMICS, 1997, 46 (01) : 18 - 23
  • [6] BUCHANAN MV, 1993, ANAL CHEM, V65, P245
  • [7] DESORPTION IONIZATION MASS-SPECTROMETRY
    BUSCH, KL
    [J]. JOURNAL OF MASS SPECTROMETRY, 1995, 30 (02): : 233 - 240
  • [8] EASTON DF, 1995, AM J HUM GENET, V56, P265
  • [9] MALDI-TOF mass spectrometric typing of single nucleotide polymorphisms with mass-tagged ddNTPs
    Fei, ZD
    Ono, T
    Smith, LM
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (11) : 2827 - 2828
  • [10] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    FENN, JB
    MANN, M
    MENG, CK
    WONG, SF
    WHITEHOUSE, CM
    [J]. SCIENCE, 1989, 246 (4926) : 64 - 71
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