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Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome

被引：50
作者：
Kralisch, S. [1 ]
Bluher, M. [1 ]
Paschke, R. [1 ]
Stumvoll, M. [1 ]
Fasshauer, M. [1 ]
机构：
[1] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 01期
关键词：
adipokine; diabetes mellitus; insulin resistance; obesity;
D O I：
10.2174/138955707779317821
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The role of adipocytes has been recently better understood. Several adipocytokines have been identified, including leptin, a main regulator of appetite and energy expenditure, adiponectin and others, as novel insulin-sensitizers/insulin-mimetics, and some others inducing insulin resistance. Adipocytokines thus represent interesting novel drug targets in the future management of obesity.
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收藏
页码：39 / 45
页数：7
相关论文
共 97 条
  • [1] Adipose tissue as an endocrine organ
    Ahima, RS
    Flier, JS
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2000, 11 (08) : 327 - 332
  • [2] Leptin
    Ahima, RS
    Flier, JS
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 : 413 - 437
  • [3] Production of plasminogen activator inhibitor 1 by human adipose tissue - Possible link between visceral fat accumulation and vascular disease
    Alessi, MC
    Peiretti, F
    Morange, P
    Henry, M
    Nalbone, G
    JuhanVague, I
    [J]. DIABETES, 1997, 46 (05) : 860 - 867
  • [4] Chemokines and leukocyte traffic
    Baggiolini, M
    [J]. NATURE, 1998, 392 (6676) : 565 - 568
  • [5] Regulation of fasted blood glucose by resistin
    Banerjee, RR
    Rangwala, SM
    Shapiro, JS
    Rich, AS
    Rhoades, B
    Qi, Y
    Wang, J
    Rajala, MW
    Pocai, A
    Scherer, PE
    Steppan, CM
    Ahima, RS
    Obici, S
    Rossetti, L
    Lazar, MA
    [J]. SCIENCE, 2004, 303 (5661) : 1195 - 1198
  • [6] Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations
    Banks, WA
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2003, 9 (10) : 801 - 809
  • [7] The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    Berg, AH
    Combs, TP
    Du, XL
    Brownlee, M
    Scherer, PE
    [J]. NATURE MEDICINE, 2001, 7 (08) : 947 - 953
  • [8] Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Berndt, J
    Klöting, N
    Kralisch, S
    Kovacs, P
    Fasshauer, M
    Schön, MR
    Stumvoll, M
    Blüher, M
    [J]. DIABETES, 2005, 54 (10) : 2911 - 2916
  • [9] Plasma levels of tumor necrosis factor-α, angiotensin II, growth hormone, and IGF-1 are not elevated in insulin-resistant obese individuals with impaired glucose tolerance
    Blüher, M
    Kratzsch, J
    Paschke, R
    [J]. DIABETES CARE, 2001, 24 (02) : 328 - 334
  • [10] Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus
    Chen, MP
    Chung, FM
    Chang, DM
    Tsai, JCR
    Huang, HF
    Shin, SJ
    Lee, YJ
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) : 295 - 299
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