Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro

被引：6

作者：

Behr, J

Empson, RM

Schmitz, D

Gloveli, T

Heinemann, U

机构：

[1] HUMBOLDT UNIV BERLIN, UNIV HOSP CHAR, INST PHYSIOL, DEPT NEUROPHYSIOL, D-10117 BERLIN, GERMANY

[2] UNIV CALIF LOS ANGELES, SCH MED, REED NEUROL RES CTR, DEPT NEUROL, LOS ANGELES, CA 90095 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, REED NEUROL RES CTR, DEPT PHYSIOL, LOS ANGELES, CA 90095 USA

[4] UNIV OXFORD, DEPT PHARMACOL, OXFORD OX1 3QT, ENGLAND

来源：

BRAIN RESEARCH | 1997年 / 773卷 / 1-2期

关键词：

subiculum; intracellular recording; bursting cell; regular firing cell; GABA(A); GABA(B); NMDA; AMPA; 5-HT;

D O I：

10.1016/S0006-8993(97)00939-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/LPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in approximate to 25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents. (C) 1997 Elsevier Science B.V.

引用

页码：217 / 222

页数：6

共 30 条

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