Resveratrol: A Natural Polyphenol with Multiple Chemopreventive Properties (Review)

被引:137
作者
Brisdelli, Fabrizia [1 ]
D'Andrea, Gabriele [1 ]
Bozzi, Argante [1 ]
机构
[1] Univ Aquila, Dept Biomed Sci & Technol, I-67100 Laquila, Italy
关键词
Resveratrol; polyphenols; chemoprevention; anti-cancer; apoptosis; cardioprotection; neuroprotection; NF-KAPPA-B; CANCER CELL-LINES; ACTIVATED PROTEIN-KINASE; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; OXIDATIVE DNA-DAMAGE; METALLOPROTEINASE INDUCER EMMPRIN; ADENINE-NUCLEOTIDE TRANSLOCATOR; VITICOLA GRAPEVINE INTERACTION; PERMEABILITY TRANSITION PORE;
D O I
10.2174/138920009789375423
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Resveratrol, a naturally occurring polyphenol, shows pleiotropic health beneficial effects, including antioxidant, anti-inflammatory, anti-aging, cardioprotective and neuroprotective activities. Due to the several protective effects and since this compound is widely distributed in the plant kingdom, resveratrol can be envisaged as a chemopreventive/curative agent introduced almost daily with the diet. Currently, a number of preclinical findings suggest resveratrol as a promising nature's weapon for cancer prevention and treatment. A remarkable progress in elucidating the molecular mechanisms underlying anti-cancer properties of resveratrol has been achieved in the last years. Concerning the resveratrol mechanism of action as a protective (vs. normal cells and tissues) and toxic (vs. cancer cells) compound, many studies focus on its antioxidant capacity as well as on its ability to trigger and favor the apoptotic cascade in malignant cells. However, a generalized mechanism of action able to explain this dual effect of resveratrol has not yet been clearly established. In addition to these important functions, resveratrol is reported to exhibit several other biological/biochemical protective effects on heart, circulation, brain and age-related diseases which are summarized in this Review.
引用
收藏
页码:530 / 546
页数:17
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