Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts

A novel and green approach for efficient and rapid synthesis of polyhydroquinoline derivatives via unsymmietnc Hantzsch reaction using organocatalysts at room temperature was reported. The process is a simple, environmentally friendly, rapid, and high yielding reaction for the synthesis of polyhydroquinoline derivatives. The catalytic efficiency of various small organocatalysts such as L-proline, trans-4-hydroxy-L-proline, L-thiaproline, DL-phenylglycine, and (-)-cinchonidine was studied under aqueous, organic, and solvent free conditions. (c) 2007 Elsevier Ltd. All rights reserved.