Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts

被引：289

作者：

Kumar, Atul ^{[1
]}

Maurya, Ram Awatar ^{[1
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

来源：

TETRAHEDRON | 2007年 / 63卷 / 09期

关键词：

Hantzsch reaction; polyhydroquinoline derivatives; Green synthesis; organocatalyst; multicomponent reaction;

D O I：

10.1016/j.tet.2006.12.074

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and green approach for efficient and rapid synthesis of polyhydroquinoline derivatives via unsymmietnc Hantzsch reaction using organocatalysts at room temperature was reported. The process is a simple, environmentally friendly, rapid, and high yielding reaction for the synthesis of polyhydroquinoline derivatives. The catalytic efficiency of various small organocatalysts such as L-proline, trans-4-hydroxy-L-proline, L-thiaproline, DL-phenylglycine, and (-)-cinchonidine was studied under aqueous, organic, and solvent free conditions. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1946 / 1952

页数：7

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