Synthesis of new (difluoromethylphosphono)azadisaccharides designed as bisubstrate analogue inhibitors for GlcNAc:β-1,4 glycosyltransferases

被引：28

作者：

Gautier-Lefebvre, I

Behr, JB

Guillerm, G

Ryder, NS

机构：

[1] UFR Sci, Chim Bioorgan Lab, UMR 6519, F-51687 Reims 2, France

[2] Novartis Res Inst, A-1235 Vienna, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00263-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report here the design, synthesis and antifungal evaluation of a new model of bisubstrate analogue inhibitor for glycosyltransferases. The synthetic strategy relies on the reductive amination between the aldehyde derived from an N-allylphosphono-pyrrolidine and an aminosugar. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1483 / 1486

页数：4

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