A new class of asymmetric phase-transfer catalysts derived from Cinchona alkaloids - Application in the enantioselective synthesis of alpha-amino acids

被引：386

作者：

Lygo, B

Wainwright, PG

机构：

[1] Department of Chemistry, University of Salford, Salford

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(97)10293-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of Cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts bearing a N-anthracenylmethyl function are presented. These catalysts show high stereocontrol in the asymmetric alkylation of a benzophenone-derived glycine-imine, and application of this process to the enantioselective synthesis of a range of alpha-amino acid esters (e.e. 67-94%) is investigated. (C) 1997 Elsevier Science Ltd.

引用

页码：8595 / 8598

页数：4

共 10 条

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