Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation

被引：50

作者：

Bank, U

Küpper, B

Reinhold, D

Hoffmann, T

Ansorge, S

机构：

[1] Otto Von Guericke Univ, Ctr Internal Med, Inst Immunol, D-39120 Magdeburg, Germany

[2] Otto Von Guericke Univ, Ctr Internal Med, Inst Expt Internal Med, D-39120 Magdeburg, Germany

[3] Probiodrug, D-06120 Halle, Germany

来源：

FEBS LETTERS | 1999年 / 461卷 / 03期

关键词：

D O I：

10.1016/S0014-5793(99)01466-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bioactivity of interleukin-6 (IL-6) was found to be dramatically reduced in fluids from sites of inflammation, Here, we provide evidence that the neutrophil-derived serine proteases elastase, proteinase 3 and cathepsin G are mainly involved in its degradation and subsequent inactivation. The initially hydrolyzed peptide bonds were detected to be Val(11)-Ala(12) and Leu(19)-Thr(20) (elastase), Phe(78)-Asn(79) (cathepsin G) and Ala(145)-Ser(146) (proteinase 3), The soluble IL-6 receptor elicits a protective effect against the IL-6 inactivation by cathepsin G only. The inactivation of IL-6 by neutrophil-derived serine proteases might act as a feedback mechanism terminating the IL-6-induced activation of neutrophils. (C) 1999 Federation of European Biochemical Societies.

引用

页码：235 / 240

页数：6

共 40 条

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