The uses of genome-wide yeast mutant collections

被引：73

作者：

Scherens, B

Goffeau, A

机构：

[1] Catholic Univ Louvain, Inst Sci Vie, B-1348 Louvain, Belgium

[2] Inst Rech Microbiol JM Wiame, B-1070 Brussels, Belgium

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 07期

关键词：

D O I：

10.1186/gb-2004-5-7-229

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We assess five years of usage of the major genome-wide collections of mutants from Saccharomyces cerevisiae: single deletion mutants, double mutants conferring 'synthetic' lethality and the 'TRIPLES' collection of mutants obtained by random transposon insertion. Over 100 experimental conditions have been tested and more than 5,000 novel phenotypic traits have been assigned to yeast genes using these collections.

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页数：8

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