Hit 'em where they live: Targeting the cancer stem cell niche

被引：107

作者：

Yang, Zeng-Jie ^{[1
]}

Wechsler-Reya, Robert J. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

CANCER CELL | 2007年 / 11卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2006.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a "vascular niche" that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.

引用

页码：3 / 5

页数：3