Behavioural pathology in Alzheimer's disease with special reference to apolipoprotein E genotype

被引：34

作者：

Gabryelewicz, T ^{[1
]}

Religa, D ^{[1
]}

Styczynska, M ^{[1
]}

Peplonska, B ^{[1
]}

Pfeffer, A ^{[1
]}

Wasiak, B ^{[1
]}

Luczywek, E ^{[1
]}

Golebiowski, M ^{[1
]}

Androsiuk, W ^{[1
]}

Czyzewski, K ^{[1
]}

Przekop, I ^{[1
]}

Barcikowska, M ^{[1
]}

机构：

[1] Polish Acad Sci, Med Res Ctr, Dept Neurodegenerat Disorders, PL-02106 Warsaw, Poland

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2002年 / 14卷 / 04期

关键词：

Alzheimer's disease; apolipoprotein E epsilon 4; behavioural symptoms; education;

D O I：

10.1159/000066020

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The aim of this study was to define the co-occurrence of behavioural symptoms and Alzheimer's disease (AD) in relation to apolipoprotein E (APOE) genotype. Probable AD patients from the Alzheimer's Day Clinic (n = 139) were assessed with the 'Behavioural Pathology in Alzheimer's Disease' rating scale, and their APOE genotype was determined. This study demonstrated no relationship between presence of the APOE epsilon4 allele and any of the behavioural symptoms assessed, including delusions, hallucinations, depression, activity disturbances, aggressiveness and anxiety. Activity disturbances, delusions, hallucinations and aggressiveness paralleled the severity of AD, increasing in frequency with the severity of the dementia. The prevalence of delusions, hallucinations, aggressiveness and depression were found to be associated with lower levels of education. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：208 / 212

页数：5

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