Impact of influenza vaccination on major cause-specific mortality

被引：96

作者：

Wang, Chong-Shan

Wang, Shan-Tair

Lai, Ching-Te

Lin, Li-Jen

Chou, Pesus ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Community Med Res Ctr, Taipei 112, Taiwan

[3] A Lein Community Hlth Ctr, Kaohsiung, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Dept Med, Inst Publ Hlth, Tainan 70101, Taiwan

[5] Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan

[6] Kaohsiung Cty Bur Hlth, Kaohsiung, Taiwan

来源：

VACCINE | 2007年 / 25卷 / 07期

关键词：

influenza vaccination; vaccine efficacy; major cause-specific mortality;

D O I：

10.1016/j.vaccine.2006.10.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of influenza vaccination is not well understood for major cause-specific mortality except pneumonia. For 10 months we followed the mortality data of 35,637 vaccinated elderly (> 65 years old) in a county with 102,698 elderly in southern Taiwan. A multivariate Cox model showed that vaccination was significantly associated with lower mortality for all causes, [hazards ratio (HR) = 0.56], stroke (HR = 0.35), renal disease (HR = 0.40), diabetes mellitus (HR = 0.45), pneumonia (HR = 0.47), COPD (HR = 0.55), malignancy (HR = 0.74), and heart diseases (HR = 0.78), p < 0.05. Influenza vaccination was strongly associated with reducing major cause-specific mortality. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1196 / 1203

页数：8

共 43 条

[21] Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient mice [J].