Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

被引：375

作者：

Ohno, Yusuke ^{[1
]}

Kihara, Akio ^{[1
]}

Sano, Takamitsu ^{[1
]}

Igarashi, Yasuyuki ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Biomembrane & Biofunct Chem, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2006年 / 1761卷 / 04期

关键词：

DHHC cysteine-rich domain; palmitoylation; protein acyltransferase;

D O I：

10.1016/j.bbalip.2006.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：474 / 483

页数：10

共 32 条

[1] Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting [J].