Novel acid-degradable and thermo-sensitive poly(N-isopropylacrylamide) hydrogels cross-linked by α,α-trehalose diacetals

被引：34

作者：

Burek, Malgorzata ^{[1
]}

Czuba, Zenon P. ^{[2
]}

Waskiewicz, Sylwia ^{[1
]}

机构：

[1] Silesian Tech Univ, Fac Chem, Dept Phys Chem & Technol Polymers, PL-44100 Gliwice, Poland

[2] Med Univ Silesia, Dept Microbiol & Immunol, PL-41808 Zabrze, Poland

来源：

POLYMER | 2014年 / 55卷 / 25期

关键词：

Thermo-sensitive; Acid-degradable hydrogel; Trehalose diacetal; SEMI-IPN HYDROGELS; SENSITIVE HYDROGELS; TREHALOSE GLYCOPOLYMERS; TEMPERATURE; POLYMER; RELEASE; ENCAPSULATION; DELIVERY; PDNA; STABILIZATION;

D O I：

10.1016/j.polymer.2014.10.032

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

New trehalose-containing hydrogels and the first hydrogels cross-linked by mono- or disaccharide acetals that are degradable in acidic medium were designed and synthesized. The cross-linking agent was obtained in acetalization reaction of trehalose with x-allyloxybenzaldehyde in which diallyl compounds were formed and used afterward in free radical copolymerization with N-isopropylacrylamide (NIPAAm) to provide thermo-sensitive hydrogels. Depending on the trehalose diacetal isomer and solvent system used in copolymerization, as well the degree of network cross-linking, these hydrogels differed in morphology, swelling and deswelling behavior and time of degradation. Compared with conventional PNIPAAm hydrogels they are degradable what makes them good materials for biomedical applications. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6460 / 6470

页数：11

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