Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines

被引：44

作者：

Mori, T

Okamoto, H

Takahashi, N

Ueda, R

Okamoto, T

机构：

[1] Nagoya City Univ, Sch Med, Dept Mol Genet, Mizuho Ku, Nagoya, Aichi 4678601, Japan

[2] Nagoya City Univ, Sch Med, Dept Internal Med 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

FEBS LETTERS | 2000年 / 465卷 / 2-3期

关键词：

p53-binding protein 2; p53; DNA-damaging agent;

D O I：

10.1016/S0014-5793(99)01726-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p53-binding protein 2 (53BP2) was identified as a binding protein to a turner suppressor p53. We examined the genetic aberrations of 53BP2 gene in various human cancer cell lines. Although no gross genomic alteration or mutation of 53BP2 gene mas observed, 53BP2 mRNA levels were highly variable. There was no association between the 53BP2 mRNA level and the p53 status. When we examined sensitivities of these cell lines to DNA-damaging agents including UV irradiation, X-ray irradiation and cis-diamine-dichloroplatinum (CDDP), we found that higher 53BP2 mRNA expression nas correlated with the sensitivity to these agents. (C) 2000 Federation of European Biochemical Societies.

引用

页码：124 / 128

页数：5

共 24 条

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[Anonymous], 1989, SYNTHETIC OLIGONUCLE

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