Synthesis of 5H-pyrazino[2,3-b]indoles from indole-2,3-dione derivatives

被引：13

作者：

Bergman, J ^{[1
]}

Vallberg, H ^{[1
]}

机构：

[1] CNT,DEPT ORGAN CHEM,S-14157 HUDDINGE,SWEDEN

来源：

ACTA CHEMICA SCANDINAVICA | 1997年 / 51卷 / 6-7期

关键词：

D O I：

10.3891/acta.chem.scand.51-0742

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of N-acetylindol-2,3-diones with ethylenediamines gave the dihydro-pyrazinones 11, which could, after dehydrogenation and deacetylation be transformed to the corresponding 5H-pyrazino[2,3-b]indoles 5. N,N-Dimethylaminoethylation of the anion of 5 occurred selectively in the 5-position. Thermolysis of 1-pyrazinylbenzotriazole gave pyrazino[1,2-a]-benzimidazole 33 and no 5H-pyrazino[2,3-b] indole.

引用

页码：742 / 752

页数：11

共 28 条

[1] THE INTERACTION OF ELLIPTICINE DERIVATIVES WITH NUCLEIC-ACIDS STUDIED BY OPTICAL AND H-1-NMR SPECTROSCOPY - EFFECT OF SIZE OF THE HETEROCYCLIC RING [J].