Middle East respiratory syndrome: current status and future prospects for vaccine development

被引：33

作者：

Du, Lanying ^{[1
]}

Jiang, Shibo ^{[2
,3
,4
]}

机构：

[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10016 USA

[2] Fudan Univ, Shanghai Med Coll, Shanghai 200433, Peoples R China

[3] Fudan Univ, Inst Med Microbiol, Key Lab Med Mol Virol, Minist Educ, Shanghai 200433, Peoples R China

[4] Minist Hlth, Shanghai, Peoples R China

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2015年 / 15卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Animal models; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; receptor-binding domain; spike protein; vaccines; RECEPTOR-BINDING DOMAIN; SYNDROME CORONAVIRUS; SPIKE PROTEIN; MERS-COV; IMMUNE-RESPONSES; SUBUNIT VACCINE; MOUSE MODEL; IMMUNIZATION; NEUTRALIZATION; GENERATION;

D O I：

10.1517/14712598.2015.1092518

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The outbreaks of Middle East respiratory syndrome (MERS) previously in Middle East and recently in South Korea have raised serious concerns worldwide, reinforcing the importance of developing effective and safe vaccines against MERS-coronavirus (MERS-CoV). A number of vaccine candidates have been developed on the basis of viral vectors, recombinant proteins, DNAs, nanoparticles, and recombinant MERS-CoV, and some of them have shown efficacy in laboratory animals. However, the paucity of financial support has made it difficult to transfer effective candidates from the preclinical stage to clinical trials. Here, we summarize currently available MERS vaccine candidates and illustrate strategies for future development, with the aim of provoking government agencies and Big Pharma to invest more funds for developing efficacious and safe MERS vaccines.

引用

页码：1647 / 1651

页数：5

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