The unfolded protein response

被引:105
作者
Schroeder, Martin [1 ]
机构
[1] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 3LE, England
基金
英国生物技术与生命科学研究理事会;
关键词
endoplasmic reticulum; molecular chaperone; recombinant protein production; signal transduction; unfolded protein response;
D O I
10.1385/MB:34:2:279
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis, attenuation of general translation, and upregulation of ER-associated degradation to decrease the unfolded protein load of the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells from an organism or a population. In this review, I will summarize our current knowledge about signal transduction pathways involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol.
引用
收藏
页码:279 / 290
页数:12
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