Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

被引：73

作者：

Park, Jinho ^{[1
]}

Yu, Mi Kyung ^{[1
]}

Jeong, Yong Yeon ^{[2
]}

Kim, Jin Woong ^{[2
]}

Lee, Kwangyeol ^{[3
]}

Phan, Vu Ngoc ^{[3
]}

Jon, Sangyong ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Life Sci, Res Ctr Biomol Nanotechnol, Cell Dynam Res Ctr, Kwangju 500712, South Korea

[2] Chonnam Natl Univ, Sch Med, Dept Radiol, Kwangju 501746, South Korea

[3] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 35期

基金：

新加坡国家研究基金会;

关键词：

RESONANCE CONTRAST AGENTS; MAGNETIC-RESONANCE; QUANTUM DOTS; MACROMOLECULAR THERAPEUTICS; DRUG-DELIVERY; NANOCRYSTALS; THERAPY; CELLS;

D O I：

10.1039/b902445j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as T2-contrast agents for magnetic resonance imaging (MRI). Herein we develop various antibiofouling amphiphilic polymer-coated SPIONs using a one-step nanoemulsion method. This methodology yielded ultrasmall polymer-coated SPIONs, of average diameter less than 30 nm, which were stable under physiological conditions. In vitro cell cytotoxicity tests revealed that no SPION showed toxicity even at relatively high concentrations. In vivo MRI with Lewis lung carcinoma (LLC) tumor-bearing mice resulted in an approximately 30% T2 signal drop in tumor tissues, indicating that the SPIONs reached such tissues via passive targeting. In summary, the ultrasmall, stable, amphiphilic polymer-coated SPIONs can be used as MRI contrast agents for cancer imaging.

引用

页码：6412 / 6417

页数：6

共 30 条

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