Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study

被引：75

作者：

Cherbuin, Nicolas ^{[1
]}

Reglade-Meslin, Chantal ^{[1
]}

Kumar, Rajeev ^{[1
,2
]}

Jacomb, Patricia ^{[1
]}

Easteal, Simon ^{[3
]}

Christensen, Helen ^{[1
]}

Sachdev, Perminder ^{[4
,5
]}

Anstey, Kaarin J. ^{[1
]}

机构：

[1] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, Dept Psychol Med, Canberra, ACT 0200, Australia

[3] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

[4] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia

[5] Inst Neuropsychiat, Sydney, NSW, Australia

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Mild cognitive impairment; Alcohol; Hypertension; BMI; Depression; IDENTIFICATION TEST AUDIT; ALZHEIMERS-DISEASE; ALCOHOL-CONSUMPTION; COMMUNITY SAMPLE; BLOOD-PRESSURE; TOTAL HEALTH; IMPAIRMENT; DEMENTIA; PROGRESSION; PERSONALITY;

D O I：

10.1159/000229025

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community. Copyright (c) 2009 S. Karger AG, Basel

引用

页码：47 / 55

页数：9

共 44 条

[31] Predictors of progression from mild cognitive impairment to Alzheimer disease
Palmer, K.
Berger, A. K.
Monastero, R.
Winblad, B.
Bachman, L.
Fratiglioni, L.
[J]. NEUROLOGY, 2007, 68 (19) : 1596 - 1602
[32] Mild cognitive impairment - Clinical characterization and outcome
Petersen, RC
Smith, GE
Waring, SC
Ivnik, RJ
Tangalos, EG
Kokmen, E
[J]. ARCHIVES OF NEUROLOGY, 1999, 56 (03) : 303 - 308
[33] Mild cognitive impairment: An overview
Petersen, Ronald C.
Negash, Selamawit
[J]. CNS SPECTRUMS, 2008, 13 (01) : 45 - 53
[34] Hypertension and the risk of mild cognitive impairment
Reitz, Christiane
Tang, Ming-Xin
Manly, Jennifer
Mayeux, Richard
Luchsinger, Jose A.
[J]. ARCHIVES OF NEUROLOGY, 2007, 64 (12) : 1734 - 1740
[35] Classification criteria for mild cognitive impairment - A population-based validation study
Ritchie, K
Artero, S
Touchon, J
[J]. NEUROLOGY, 2001, 56 (01) : 37 - 42
[36] Non-linear relationships between cognitive function and alcohol consumption in young, middle-aged and older adults: the PATH Through Life Project
Rodgers, B
Windsor, TD
Anstey, KJ
Dear, KBG
Jorm, AF
Christensen, H
[J]. ADDICTION, 2005, 100 (09) : 1280 - 1290
[37] DEVELOPMENT OF THE ALCOHOL-USE DISORDERS IDENTIFICATION TEST (AUDIT) - WHO COLLABORATIVE PROJECT ON EARLY DETECTION OF PERSONS WITH HARMFUL ALCOHOL-CONSUMPTION .2.
SAUNDERS, JB
AASLAND, OG
BABOR, TF
DELAFUENTE, JR
GRANT, M
[J]. ADDICTION, 1993, 88 (06) : 791 - 804
[38] Cigarette Smoke Exposure Promotes Arterial Thrombosis and Vessel Remodeling after Vascular Injury in Apolipoprotein E-Deficient Mice
Schroeter, Marco R.
Sawalich, Matthias
Humboldt, Tim
Leifheit, Maren
Meurrens, Kris
Berges, An
Xu, Haiyan
Lebrun, Stefan
Wallerath, Thomas
Konstantinides, Stavros
Schleef, Raymond
Schaefer, Katrin
[J]. JOURNAL OF VASCULAR RESEARCH, 2008, 45 (06) : 480 - 492
[39] Update on hypertension and Alzheimer's disease
Skoog, Ingmar
Gustafson, Deborah
[J]. NEUROLOGICAL RESEARCH, 2006, 28 (06) : 605 - 611
[40] Alcohol consumption, mild cognitive impairment, and progression to dementia
Solfrizzi, V.
D'Introno, A.
Colacicco, A. M.
Capurso, C.
Del Parigi, A.
Baldassarre, G.
Scapicchio, P.
Scafato, E.
Amodio, M.
Capurso, A.
Panza, F.
[J]. NEUROLOGY, 2007, 68 (21) : 1790 - 1799

← 1 2 3 4 5 →