An in situ gelling system for parenteral delivery

被引:63
作者
Haglund, BO [1 ]
Josi, R [1 ]
Himmelstein, KJ [1 ]
机构
[1] UNIV NEBRASKA,MED CTR,DEPT PHARMACEUT SCI,OMAHA,NE 68198
关键词
polymer complex; polyethylene glycol PEG; polymethacrylic acid PMA; polyacrylic acid PAA; drug delivery;
D O I
10.1016/0168-3659(96)01333-8
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polymer complexes formed by electrostatic interactions or hydrogen bonds between polymer strands can be utilized as a drug delivery system, as its ability to undergo a sol-gel transformation in response to changes in temperature, pH, and solvent concentration can lead to an in situ forming delivery system. A polymer complex of polyacrylic or polymethacrylic acid and polyethylene glycol, previously reported to be formed primarily by hydrogen bonds, is being investigated as such a system. Stable below pH less than or equal to 5.7, the complex is insoluble in water but dissolves in a hydroalcoholic solvent to yield a clear viscous solution. Upon injection, the diffusion of ethanol from the liquid transforms the system into a gel upon contact with physiological conditions. The gel disappears from the site with time due to dissociation of the complex. Water-soluble and low molecular weight, the dissociated components can be eliminated by glomerular filtration. Using a concentration of 50% ethanol as the cosolvent, the system can be injected by syringe. Thus, an interpolymer complex of polymethacrylic acid and polyethylene glycol may be utilized as a parenteral controlled-release drug delivery system.
引用
收藏
页码:229 / 235
页数:7
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