2'-fluoro-2',3'-dideoxyarabinosyladenine (F-ddA): Activity against drug-resistant human immunodeficiency virus strains and clades A-E

被引：16

作者：

Driscoll, JS

Mayers, DL

Bader, JP

Weislow, OS

Johns, DG

Buckheit, RW

机构：

[1] WALTER REED ARMY INST RES, ROCKVILLE, MD 20850 USA

[2] NCI, ANTIVIRAL EVALUAT BRANCH, ROCKVILLE, MD 20852 USA

[3] SRA TECHNOL, ROCKVILLE, MD 20850 USA

[4] FREDERICK CANC RES & DEV CTR, SO RES INST, VIROL RES GRP, FREDERICK, MD 21701 USA

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1997年 / 8卷 / 02期

关键词：

HIV; cross-resistance; F-ddA; clade;

D O I：

10.1177/095632029700800204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2'-Fluoro-2',3'-dideoxyarabinosyladenine (F-ddA), an anti-human immunodeficiency virus (HIV) drug currently in clinical trial, was compared with zidovudine (ATT), ddl and ddC for anti-HIV activity and potency in HIV-1 strains both sensitive and resistant to zidovudine, ddl and non-nucleoside reverse transcriptase inhibitors. A variety of host cell systems [MT-2, MT-4, phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC)] was used. F-ddA was effective against each of the drug-resistant isolates, including the strain resistant to ddl, the other purine dideoxynucleoside evaluated in this study. The anti-HIV-1 activities of F-ddA and zidovudine were also determined against clades A-E in PHA-PBMCs. Although activities were similar, zidovudine was significantly more potent than F-ddA in the PHA-PBMC system.

引用

页码：107 / 111

页数：5

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