Stabilization of microtubules by combretastatin D derivatives

被引：9

作者：

Couladouros, EA

Li, TH

Moutsos, VI

Pitsinos, EN

Soufli, IC

机构：

[1] Agr Univ Athens, Chem Labs, Athens 11855, Greece

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] NCSR Demokritos, Inst Chem Phys, Lab Organ & Bioorgan Chem, GR-15310 Athens, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00503-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2927 / 2928

页数：2

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