The EH network

被引:114
作者
Santolini, E
Salcini, AE
Kay, BK
Yamabhai, M
Di Fiore, PP
机构
[1] Ist Europeo Oncol, Dept Expt Oncol, I-20141 Milan, Italy
[2] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA
[3] Univ Bari, Ist Microbiol, I-70121 Bari, Italy
关键词
EH; domains; Eps15; endocytosis;
D O I
10.1006/excr.1999.4694
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic "accessory" proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an "integrator" of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation. (C) 1999 Academic Press.
引用
收藏
页码:186 / 209
页数:24
相关论文
共 196 条
[21]   A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C-elegans [J].
Clark, SG ;
Shurland, DL ;
Meyerowitz, EM ;
Bargmann, CI ;
vanderBliek, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10438-10443
[22]   Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization [J].
Coda, L ;
Salcini, AE ;
Confalonieri, S ;
Pelicci, G ;
Sorkina, T ;
Sorkin, A ;
Pelicci, PG ;
Di Fiore, PP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (05) :3003-3012
[23]   MODULAR BINDING DOMAINS IN SIGNAL-TRANSDUCTION PROTEINS [J].
COHEN, GB ;
REN, RB ;
BALTIMORE, D .
CELL, 1995, 80 (02) :237-248
[24]   An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes [J].
Corral, J ;
Lavenir, I ;
Impey, H ;
Warren, AJ ;
Forster, A ;
Larson, TA ;
Bell, S ;
McKenzie, ANJ ;
King, G ;
Rabbitts, TH .
CELL, 1996, 85 (06) :853-861
[25]   HIV-1 auxiliary proteins: Making connections in a dying cell [J].
Cullen, BR .
CELL, 1998, 93 (05) :685-692
[26]   Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors [J].
Cupers, P ;
Jadhav, AP ;
Kirchhausen, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (04) :1847-1850
[27]   Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15 (EPS15) [J].
Cupers, P ;
ter Haar, E ;
Boll, W ;
Kirchhausen, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) :33430-33434
[28]   A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals [J].
David, C ;
McPherson, PS ;
Mundigl, O ;
DeCamilli, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :331-335
[29]   Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain [J].
de Beer, T ;
Carter, RE ;
Lobel-Rice, KE ;
Sorkin, A ;
Overduin, M .
SCIENCE, 1998, 281 (5381) :1357-1360
[30]   Identification of the major synaptojanin-binding proteins in brain [J].
deHeuvel, E ;
Bell, AW ;
Ramjaun, AR ;
Wong, K ;
Sossin, WS ;
McPherson, PS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8710-8716